Methylamine → N-methyl-2-(trifluoromethyl)benzamide
Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[CH3:14][NH2:15]>C(Cl)(Cl)Cl>[CH3:14][NH:15][C:5](=[O:6])[C:4]1[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=1[C:2]([F:13])([F:12])[F:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-(Trifluoromethyl)benzoyl chloride and methylamine (2M, THF solution) were reacted in chloroform at room temperature to obtain N-methyl-2-(trifluoromethyl)benzamide.
Sources & evidence
- ORD record
- ord-ab7824f87fc8483caed02b6564f89f04
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07776897B2
Reaction notes
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