Ethyl pyruvate → ethyl (2E)-2-[(3-nitrophenyl)hydrazinylidene]propanoate
Reaction equation
Cl.[N+:2]([C:5]1[CH:6]=[C:7]([NH:11][NH2:12])[CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3].[CH2:13]([O:15][C:16](=[O:20])[C:17](=O)[CH3:18])[CH3:14]>C(O)C>[N+:2]([C:5]1[CH:6]=[C:7]([NH:11]/[N:12]=[C:17](\[CH3:18])/[C:16]([O:15][CH2:13][CH3:14])=[O:20])[CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
(3-Nitrophenyl)hydrazine hydrochloride (30 g, 0.16 mol) and 2-oxo-propionic acid ethyl ester (22 g, 0.19 mol) were dissolved in ethanol (300 mL). The mixture was stirred at room temperature for 4 h before the solvent was evaporated under reduced pressure to give (E)-ethyl 2-(2-(3-nitrophenyl)hydrazono)propanoate, which was used directly in the next step