Diethyl(4-nitrophenyl)phosphonate → P-(4-Nitrophenyl)phosphonic acid

HRID 511220Notes

Reaction equation

HRID 511220 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([P:10](=[O:17])([O:14]CC)[O:11]CC)=[CH:6][CH:5]=1)([O-:3])=[O:2]>Cl>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([P:10](=[O:11])([OH:14])[OH:17])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 284865Diethyl(4-nitrophenyl)phosphonate

Product 1

HCID 196997P-(4-Nitrophenyl)phosphonic acidYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of diethyl (4-nitrophenyl)phosphonate (60 g, 230 mmol) in 250 mL of concentrated HCl (aq) was stirred at reflux overnight. The excess HCl was removed under reduced pressure and the product used in further chemistries without purification (46.8 g, yield: 100%).

Workup

  1. temperatureat reflux overnight
  2. customThe excess HCl was removed under reduced pressure
  3. customthe product used in further chemistries without purification (46.8 g, yield: 100%)

Sources & evidence

ORD record
ord-00ef7beb8b9644988eeff1d44a1fe193
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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