Isonicotinic Acid → 4-(2,3-Dimethoxybenzoyl)pyridine

HRID 51246

Reaction equation

HRID 51246 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[CH:3][CH:2]=1.[C:10]1([O:18][CH3:19])[C:11](=[CH:14][CH:15]=[CH:16][CH:17]=1)[O:12][CH3:13]>>[CH3:13][O:12][C:11]1[C:10]([O:18][CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=1[C:7]([C:4]1[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=1)=[O:9]

Participants

3

Reactant 2

HCID 5922Isonicotinic AcidHCID 7043Veratrole

Product 1

HCID 4285494-(2,3-Dimethoxybenzoyl)pyridine

Procedure

In Scheme H, step d, 4-pyridinecarboxylic acid (18) is reacted with lithiated veratrole to give 4-(2,3-dimethoxybenzoyl)pyridine (12).

Sources & evidence

ORD record
ord-b18ab3eab1bb4fed8f9d7a995fcc80a2
Source dataset
uspto-grants-2004_03
Patent number
US06713627B2

Linked notes

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