3-Chlorophenylacetic acid → Ethyl 4-(3-chlorophenyl)-3-oxobutanoate

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[CH3:12][C:13]1(C)[O:18]C(=O)[CH2:16][C:15](=O)[O:14]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9](=[O:11])[CH2:12][C:13]([O:14][CH2:15][CH3:16])=[O:18])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 158793-Chlorophenylacetic acid

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 10538052Ethyl 4-(3-chlorophenyl)-3-oxobutanoateYield 43%

Procedure

The title compound was prepared in 43% yield from 2-(3-chlorophenyl)acetic acid and 2,2-dimethyl-1,3-dioxane-4,6-dione according to the procedure for the preparation of Example 162, part A.

Sources & evidence

ORD record: ord-9de20536820646be8e2762fe8b681278
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09107916B2

Reaction notes

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