Potassium Carbonate → 1-Ethynyl-4-(1-isopropoxycyclopropyl)-benzene
Reaction equation
[CH:1]([O:4][C:5]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[C:15][Si](C)(C)C)=[CH:10][CH:9]=2)[CH2:7][CH2:6]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2([O:4][CH:1]([CH3:3])[CH3:2])[CH2:6][CH2:7]2)=[CH:9][CH:10]=1)#[CH:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Using General Procedure E; [4-(1-isopropoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 65, 260.0 mg, 0.96 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.
Sources & evidence
- ORD record
- ord-0bcab813fe974ca8ba0c2166eb2e9a16
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06713647B2
Reaction notes
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