Hydrochloric Acid → 2-(difluoromethyl)benzoic Acid
Reaction equation
[F:1][CH:2]([F:13])[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>CO>[F:1][CH:2]([F:13])[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of methyl 2-(difluoromethyl)benzoate 52 (7 g, 38 mmol) and 10% aq. NaOH (100 mL) in MeOH (50 mL) was heated at reflux for 30 min. The pH was adjusted to 4 by the addition of 3N HCl. The resulting solid was collected by filtration, rinsed with H2O and dried to give 53 (6 g, 93% yield).
Workup
- temperaturewas heated
- temperatureat reflux for 30 min
- filtrationThe resulting solid was collected by filtration
- washrinsed with H2O
- customdried
Sources & evidence
- ORD record
- ord-3140ad8e436a4c06bf35fe024b0e4793
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09326986B2
Reaction notes
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