Trifluoroacetic acid → 6-Oxa-9-azaspiro(4.5)decane
Reaction equation
[CH2:1]1[C:5]2([CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][O:6]2)[CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:4]1[C:5]2([CH2:10][NH:9][CH2:8][CH2:7][O:6]2)[CH2:1][CH2:2][CH2:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a of solution 1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate (200 mg, 0.829 mmol, available from Tyger Scientific Inc) in DCM (3 ml) was added trifluoroacetic acid (TFA) (0.5 ml). The resulting colourless yellow solution was stirred at room temperature for 24 hr. The solvent was evaporated to give the title compound as a grey oil (203 mg).
Workup
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-3c162852ea0642de9223ca168f21b6b1
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09326987B2
Reaction notes
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