4-Thiazolecarboxylic acid → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]thiazole-4-carboxamide

HRID 52069

Reaction equation

HRID 52069 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH2:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[S:20]1[CH:24]=[C:23]([C:25](O)=[O:26])[N:22]=[CH:21]1>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:25]([C:23]3[N:22]=[CH:21][S:20][CH:24]=3)=[O:26])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 3042714-Thiazolecarboxylic acidHCID 136724732-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)-

Product 1

HCID 67725963N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]thiazole-4-carboxamideYield 68%

Procedure

Following a procedure similar to that described in Example 13, but using 4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenylamine and 4-thiazolecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 68% yield.

Sources & evidence

ORD record
ord-5cfa5dff5781453181f01f9c06a67116
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Linked notes

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