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Sodium Hydroxide → (4aS,10bR)-8-(4-methoxyphenoxy)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline

HRID 521000
Notes
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Reaction equation

HRID 521000 reaction equation
[OH-].[Na+].FC(F)(F)C([N:7]1[C@@H:16]2[C@@H:11]([C:12]3[CH:20]=[CH:19][C:18]([O:21][C:22]4[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=4)=[CH:17][C:13]=3[CH2:14][CH2:15]2)[CH2:10][CH2:9][CH2:8]1)=O>O1CCCC1>[CH3:29][O:28][C:25]1[CH:24]=[CH:23][C:22]([O:21][C:18]2[CH:19]=[CH:20][C:12]3[C@@H:11]4[C@H:16]([CH2:15][CH2:14][C:13]=3[CH:17]=2)[NH:7][CH2:8][CH2:9][CH2:10]4)=[CH:27][CH:26]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86654073cis-2,2,2-trifluoro-1-[8-(4-methoxy-phenoxy)-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-4-yl]-ethanone

Product 1

HCID 86654075(4aS,10bR)-8-(4-methoxyphenoxy)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
35 °C

Procedure

1 M aqueous NaOH solution (10 mL) is added to a solution of cis-2,2,2-trifluoro-1-[8-(4-methoxy-phenoxy)-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-4-yl]ethanone (0.95 g) in tetrahydrofuran (10 mL) at room temperature. The resulting solution is stirred at 35° C. overnight and then cooled to room temperature. The solution is extracted with ethyl acetate, the combined extracts are washed with brine and dried (Na2SO4). The solvent is evaporated and the residue is chromatographed on silica gel (dichloromethane/methanol containing 1% NH3 95:5→70:30) to give the title compound as a colorless resin-like solid. Yield: 0.64 g (88% of theory); LC (method 1): tR=2.75 min; Mass spectrum (ESI+): m/z=310 [M+H]+.

Workup

  1. temperaturecooled to room temperature
  2. extractionThe solution is extracted with ethyl acetate
  3. washthe combined extracts are washed with brine
  4. dry with materialdried (Na2SO4)
  5. customThe solvent is evaporated
  6. customthe residue is chromatographed on silica gel (dichloromethane/methanol containing 1% NH3 95:5→70:30)

Sources & evidence

ORD record
ord-ff22355466a24688b9a70b5a0c334e19
Source dataset
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09328072B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes