Methyl iodide → Methyl 3-bromo-5-fluoro-4-methoxybenzoate
Reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([OH:11])=[C:6]([Br:12])[CH:5]=1.[C:14](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:14])=[C:6]([Br:12])[CH:5]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
6 g (24.09 mmol) of the product obtained in step 1 were dissolved in 60 ml of acetone, 10.13 g (2.270 mmol) of potassium carbonate and 6.84 g (48.18 mmol) of iodomethane were added, and the mixture was stirred for 4 days. Then is was filtered and evaporated. The resulting product (5.8 g) was used in the next step without further purification.
Workup
- filtrationThen is was filtered
- customevaporated
- customThe resulting product (5.8 g) was used in the next step without further purification
Sources & evidence
- ORD record
- ord-655597f546b3408f909ac54e3c6d0729
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09328071B2
Reaction notes
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