Ammonium Hydroxide → Thiophen-2-acetamide
Reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7](Cl)=[O:8].[NH4+:10].[OH-]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH2:10])=[O:8]Participants
3
Procedure
To a mixture of concentrated NH4OH (100 mL) and ice was added 2-thiopheneacetyl chloride (13.0 g, 80.9 mmol). The desired compound crystallized from the reaction mixture. Recrystallization from hot water gave 2-thiopheneacetamide (8.08 g, 64% yield) as white crystals. mp 146°-147° C.
Workup
- customThe desired compound crystallized from the reaction mixture
- customRecrystallization from hot water
Sources & evidence
- ORD record
- ord-d50cdad937b642df885f4e3877aa82ac
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05616596
Reaction notes
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