Hydrochloric Acid → HCID 178463365, compound

Racemic-N-(1-(1H-1,2,3-triazol-4-yl)ethyl)-2-methylpropane-2-sulfinamide (Preparation 63, 1.09 g, 5.04 mmol) was dissolved in methanol (10 mL). 4M HCl in MeOH (10 mL) was added and the mixture was stirred at room temperature for 5 hours. The reaction was concentrated in vacuo and triturated with TBME (50 mL), diethyl ether (20 mL) and finally with acetonitrile (20 mL). The remaining gum was azeotroped with methanol (10 mL) followed by toluene (10 mL) to afford the title compound as a pale yellow gum (780 mg, 100%).

1. concentrationThe reaction was concentrated in vacuo
2. customtriturated with TBME (50 mL), diethyl ether (20 mL) and finally with acetonitrile (20 mL)
3. customThe remaining gum was azeotroped with methanol (10 mL)

ORD record

ord-621effb280fa483c92070a0ba7f00b18

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09328096B2