Potassium Carbonate → S 20928

HRID 52289

Reaction equation

HRID 52289 reaction equation
Cl.[C:2]1([CH2:12][CH2:13][NH2:14])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH:21]1([C:25](Cl)=[O:26])[CH2:24][CH2:23][CH2:22]1>O.C(Cl)(Cl)Cl>[C:2]1([CH2:12][CH2:13][NH:14][C:25]([CH:21]2[CH2:24][CH2:23][CH2:22]2)=[O:26])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 78705Cyclobutanecarbonyl chlorideHCID 123704372-(1-Naphthyl)ethylamine hydrochloride

Product 1

HCID 127856S 20928

Reagents, catalysts & solvents 1

HCID 22418719Chloroform waterSolvent

Procedure

0.01 mol of N-[2-(1-naphthyl)ethyl]amine hydrochloride is dissolved in a water/chloroform (40: 60; vol/vol ) mixture, and 0.02 mol of potassium carbonate is then added with magnetic stirring. The reaction mixture is cooled in an ice bath, and 0.01 mol of cyclobutanecarbonyl chloride is then added dropwise with magnetic stirring.

Workup

  1. additionis then added with magnetic stirring
  2. temperatureThe reaction mixture is cooled in an ice bath

Sources & evidence

ORD record
ord-8e4b4b7fd8854a2684e0c0c78407b175
Source dataset
uspto-grants-1997_04
Patent number
US05616614

Linked notes

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