Carbon Disulfide → Cyanomethyl methyl(4-pyridyl)carbamodithioate

Temperature

-10 °C

To a cold (−10° C.) solution of 4-(methylamino)pyridine (9 g, 0.0841 mol) in anhydrous THF (200 mL) was added n-butyl lithium (2.5M, 44 mL, 0.11 mol) dropwise such that the temperature remained below −7° C. The resulting pale yellow suspension was allowed to stir for about one hour at −10° C. To this mixture was added carbon disulfide (10.2 mL, 12.936 g, 0.168 mol) over one hour at 0° C. and the mixture was left to stir overnight at room temperature. The resultant mixture was cooled to 0° C. and bromoacetonitrile (8.8 mL, 15.14 g, 0.126 mol) was added dropwise. The resultant mixture was stirred at room temperature for two hours. The reaction mixture was extracted with diethyl ether (400 mL) and washed with saturated NaHCO3 and brine. The organic layers were combined and dried (Na2SO4) and reduced to a dark brown oil. The crude was dissolved in ethyl acetate and purified by column chromatography (silica gel 60, 70-230 mesh, 30% ethyl acetate in n-hexane as eluent), gave the title compound as off-white cubes (11.05 g, 59% yield). 1H nmr (CDCl3) δ (ppm) 3.78 (s, 3H, N—CH3); 4.05 (s, 2H, SCH2CN); 7.25 (m, 2H, m-ArH); 8.75 (m, 2H, o-ArH).

1. customremained below −7° C
2. waitthe mixture was left
3. stirringto stir overnight at room temperature
4. extractionThe reaction mixture was extracted with diethyl ether (400 mL)
5. washwashed with saturated NaHCO3 and brine
6. dry with materialdried (Na2SO4)
7. dissolutionThe crude was dissolved in ethyl acetate
8. custompurified by column chromatography (silica gel 60, 70-230 mesh, 30% ethyl acetate in n-hexane as eluent)

ORD record

ord-e5b42300254b4e7eb9a1fb4a0c7325d9

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09340498B2