Hydrazine hydrate (1:1) → 5-(3,4-dimethoxyphenyl)-4,4-diethyl-2,4-dihydro-3H-pyrazol-3-one

HRID 524308

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6](Cl)=O.[CH2:14]([CH:16]([CH2:21][CH3:22])[C:17](OC)=[O:18])[CH3:15].O.[NH2:24][NH2:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:6]2[C:16]([CH2:21][CH3:22])([CH2:14][CH3:15])[C:17](=[O:18])[NH:24][N:25]=2)[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]

Participants

Reactant 3

HCID 24654Hydrazine hydrate (1:1)

HCID 69951Methyl 2-ethylbutyrate

HCID 77070Veratroyl chloride

Product 1

HCID 666166225-(3,4-dimethoxyphenyl)-4,4-diethyl-2,4-dihydro-3H-pyrazol-3-one

Procedure

Prepared analogously as described for the example C5 using 3,4-dimethoxybenzoyl chloride, methyl 2-ethylbutanoate and hydrazine hydrate as starting compounds.

Workup

customPrepared analogously

Sources & evidence

ORD record: ord-57e327fea8d04f8196837e41f409bb21
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340522B2

Linked notes

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