2-Amino-6-methoxybenzothiazole → 2-Cyano-6-methoxy benzothiazole

HRID 524800

Reaction equation

HRID 524800 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[N:7]=[C:8](N)[S:9][C:5]=2[CH:4]=1.[C:13]([Cu])#[N:14]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[N:7]=[C:8]([C:13]#[N:14])[S:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 156302-Amino-6-methoxybenzothiazoleHCID 178418546HCID 178418546, compound

Product 1

HCID 3421092-Cyano-6-methoxy benzothiazoleYield 22.1%

Procedure

6-methoxybenzo[d]thiazol-2-amine (9 g, 50 mmol) was reacted with CuCN (8.96 g, 100 mmol) according to the procedure as described in Example 61, Step A to give the title compound as a white solid (2.1 g, 22%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-f2c31f5651ce4d4bbb0f55cdedf1b63b
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Linked notes

Loading…