1,4-Dioxane → N-(3-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[O:21][CH3:22].[CH3:23][C:24]1[C:33]2[CH:32]=[N:31][C:30](S(C)=O)=[N:29][C:28]=2[N:27]([C:37]2[CH:38]=[C:39]([NH:43][C:44](=[O:47])[CH:45]=[CH2:46])[CH:40]=[CH:41][CH:42]=2)[C:26](=[O:48])[CH:25]=1.CCN(C(C)C)C(C)C.O1CCOCC1>C(O)(C)(C)C>[CH3:22][O:21][C:3]1[CH:4]=[C:5]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:6]=[CH:7][C:2]=1[NH:1][C:30]1[N:31]=[CH:32][C:33]2[C:24]([CH3:23])=[CH:25][C:26](=[O:48])[N:27]([C:37]3[CH:38]=[C:39]([NH:43][C:44](=[O:47])[CH:45]=[CH2:46])[CH:40]=[CH:41][CH:42]=3)[C:28]=2[N:29]=1