HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

1,4-Dibromobutane → 2-(Butyloxy)-9-[4-(hexahydro-1H-azepin-yl)butyl]-8-(methyloxy)-9H-purin-6-amine

HRID 527783
Notes
Print preview

Reaction equation

HRID 527783 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([O:12][C:13]1[NH:14][C:15]([NH2:24])=[C:16]2[C:20]([N:21]=1)=[N:19][C:18]([O:22][CH3:23])=[N:17]2)[CH2:9][CH2:10][CH3:11].Br[CH2:26][CH2:27][CH2:28][CH2:29]Br.[NH:31]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH2:8]([O:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[N:19]2[CH2:26][CH2:27][CH2:28][CH2:29][N:31]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11]
ParticipantsProcedureSources & evidenceReaction notes

Participants

4

Reactant 3

HCID 80561,4-DibromobutaneHCID 8119AzepaneHCID 178450357HCID 178450357, compound

Product 1

HCID 592526192-(Butyloxy)-9-[4-(hexahydro-1H-azepin-yl)butyl]-8-(methyloxy)-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 20 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,4-dibromobutane and hexahydro-1H-azepine.

Sources & evidence

ORD record
ord-356387bbff25499daa40cd9cabbf3bc2
Source dataset
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09346806B2

Reaction notes

Loading…

On this pageParticipantsProcedureSources & evidenceReaction notes