Ethyl (chloroformyl)acetate → Ethyl thiazole-5-carboxylate
Reaction equation
Cl[CH:2]([CH:8]=O)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH:10]([NH2:12])=[S:11]>>[C:3]([C:2]1[S:11][CH:10]=[N:12][CH:8]=1)([O:5][CH2:6][CH3:7])=[O:4]Participants
3
Procedure
According to the procedure of Mashraqui and Keehn (J. Am. Chem. Soc. 1982, 104, 4461), ethyl α-chloro-α-formylacetate was condensed with thioformamide and vacuum distilled to provide 5.65 g (33%) of the desired compound.
Workup
- distillationdistilled
Sources & evidence
- ORD record
- ord-f3518c71ebc14df68b241e1171fe4697
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05616714
Reaction notes
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