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Flurbiprofen → 2-Hydroxyethyl Methacrylate

HRID 5285
Notes
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Reaction equation

HRID 5285 reaction equation
C[C@H:2](NC([C@@H](NC([C@@H](NC(N[C@H](C(O)=O)CC(C)C)=O)[C@H]1NC(=N)NCC1)=O)CCC(N)=O)=O)[CH:3]=[O:4].[CH3:37][CH:38]([C:52]([OH:54])=[O:53])[C:39]1C=CC(C2C=CC=CC=2)=C(F)C=1.C[C@H]1[C@](O)(C(COP([O-])(O)=O)=O)[C@]2(C)[C@H]([C@H]3[C@](F)([C@@H](O)C2)[C@]2(C)C(=CC(C=C2)=O)CC3)C1.[Na+].C1[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H](O)[C@@H]1N.OS(O)(=O)=O>>[C:52]([O:54][CH2:2][CH2:3][OH:4])(=[O:53])[C:38]([CH3:37])=[CH2:39]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 4

HCID 3394FlurbiprofenHCID 197162Neomycin SulfateHCID 23667621Dexamethasone 21-(sodium hydrogen phosphate)HCID 178418625HCID 178418625, compound

Product 1

HCID 133602-Hydroxyethyl Methacrylate

Procedure

A mixture was prepared by combining aprotinin 1 g.; elastatinal 0.1 g.; flurbiprofen 0.1 g.; dexamethasone sodium phosphate 0.1 g.; neomycin sulfate; and physiological saline up to 100 g. A contact lens form the crosslinked polymer of 2-hydroxyethyl methacrylate (38 percent by weight of equilibrium water) was swelled in the given solution for 24 hours. The contact lens was used for the treatment of nonhealing corneal erosions. Within a week after application the reepithalization was sped up. Extraordinary results were attained after severe etching and burning of the anterior segment of the eye. The intraocular inflammation did not develop, the cornea did not exhibit ulceration and healed with a scar to place within a month. The transparency recovered in the periphery of the cornea.

Workup

  1. customA mixture was prepared

Sources & evidence

ORD record
ord-e39f5bba0a6d4f2e88f4a74a2a9aada9
Source dataset
uspto-grants-1993_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05244673

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes