Methyl iodide → 3-Methoxy-2-nitropyridine

HRID 529171

Reaction equation

[N+:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][N:5]=1)([O-:3])=[O:2].[C:11](=O)([O-])[O-].[K+].[K+].CI>>[CH3:11][O:10][C:9]1[C:4]([N+:1]([O-:3])=[O:2])=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 270573-Hydroxy-2-nitropyridine

Product 1

HCID 5560633-Methoxy-2-nitropyridineYield 97.4%

Procedure

The similar reaction as described in Reference Example 9 by using 2-nitro-3-hydroxypyridine (7.0 g), potassium carbonate (6.91 g) and methyl iodide (4.67 ml) gave the title compound (7.5 g) as crystalline powders.

Workup

customThe similar reaction

Sources & evidence

ORD record: ord-5fbd7c38c66248e587ceea4b3a00c236
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09346822B2

Linked notes

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