Glycine ethyl ester, hydrochloride → N-Ethoxycarbonylmethyl-2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-hydroxymethylimidazole-5-carboxamide

HRID 52944

Reaction equation

HRID 52944 reaction equation
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26](ON3C(=O)CCC3=O)=[O:27])=[C:24]([CH2:36][OH:37])[N:23]=[C:22]2[CH2:38][CH2:39][CH2:40][CH3:41])=[CH:16][CH:15]=1)=[O:7])(C)(C)C.Cl.[NH2:43][CH2:44][C:45]([O:47][CH2:48][CH3:49])=[O:46]>C(N(CC)CC)C>[CH2:48]([O:47][C:45]([CH2:44][NH:43][C:26]([C:25]1[N:21]([CH2:20][C:17]2[CH:16]=[CH:15][C:14]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[C:6]([OH:7])=[O:5])=[CH:19][CH:18]=2)[C:22]([CH2:38][CH2:39][CH2:40][CH3:41])=[N:23][C:24]=1[CH2:36][OH:37])=[O:27])=[O:46])[CH3:49]

Participants

4

Reactant 2

HCID 2723640Glycine ethyl ester, hydrochlorideHCID 19036239Succinimido 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-hydroxymethylimidazole-5-carboxylate

Product 1

HCID 19036286N-Ethoxycarbonylmethyl-2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-hydroxymethylimidazole-5-carboxamide

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Following a procedure similar to that described in Example 53, but using 0.307 g of succinimido 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-hydroxymethylimidazole-5-carboxylate [prepared as described in Example 52(a)], 89 mg of ethyl glycinate hydrochloride and 0.089 ml of triethylamine, 0.202 g of the

Sources & evidence

ORD record
ord-d8ae651d28ae461294e4f692d26523fc
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Linked notes

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