Hydrochloric Acid → (7S,10aR,Z)-7-amino-1,2,3,4,7,8-hexahydropyrido[1,2-a]azepin-6(10aH)-one hydrochloride
Reaction equation
[ClH:1].[O:2]=[C:3]1[N:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@@H:8]2[CH:7]=[CH:6][CH2:5][C@@H:4]1[NH:14]C(=O)OC(C)(C)C>O1CCOCC1>[ClH:1].[NH2:14][C@@H:4]1[C:3](=[O:2])[N:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@@H:8]2[CH:7]=[CH:6][CH2:5]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of HCl (4.0 N in 1,4-dioxane, 2.33 mL, 9.32 mmol) was added to a 0° C. solution of tert-butyl (7S,10aR,Z)-6-oxo-1,2,3,4,6,7,8,10a-octahydropyrido[1,2-a]azepin-7-ylcarbamate (653 mg, 2.33 mmol) in 1,4-dioxane (0.93 mL). The reaction mixture was then stirred at rt for 1 hr. The reaction mixture was concentrated and dried under vacuum to give (7S,10aR,Z)-7-amino-1,2,3,4,7,8-hexahydropyrido[1,2-a]azepin-6(10aH)-one hydrochloride (504 mg, 2.33 mmol, 100% yield) as a tan solid. Anal. Calcd. for C10H16N2O m/z 180.2. found: 181.0 (M+H)+.