Cesium carbonate → (1S)-2,2-difluoro-1-(3'-fluoro-5'-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-4-yl)ethanol

Temperature

110 °C

Palladium(II) acetate (33.5 mg, 0.149 mmol) was added to a mixture of (1S)-1-(3′-amino-5′-fluorobiphenyl-4-yl)-2,2-difluoroethanol (222 mg, 0.747 mmol), cesium carbonate (487 mg, 1.494 mmol), and 2-chloro-4-(trifluoromethyl)pyrimidine (143 mg, 0.784 mmol) in degassed (by sparging with Argon) dioxane (8 mL). The mixture was heated to 110° C. for 5 hours. Upon cooling to room temperature, the reaction mixture was diluted with saturated aqueous NaHCO3, extracted with ethyl acetate, washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (ethyl acetate/toluene) to afford (1S)-2,2-difluoro-1-(3′-fluoro-5′-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}biphenyl-4-yl)ethanol. MS ESI calc'd. for C19H14F6N3O [M+H]+ 414, found 414. 1H NMR (500 MHz, Acetone-d6): δ 9.48 (s, 1H); 8.89 (d, J=4.9 Hz, 1H); 8.02 (d, J=2.1 Hz, 1H); 7.89 (dd, J=11.4, 2.4 Hz, 1H); 7.76 (d, J=8.0 Hz, 2H); 7.63 (d, J=8.0 Hz, 2H); 7.32 (d, J=4.9 Hz, 1H); 7.19-7.15 (m, 1H); 6.01 (td, J=55.9, 4.3 Hz, 1H); 5.37 (d, J=4.9 Hz, 1H); 5.00-4.93 (m, 1H).

1. customin degassed (by sparging with Argon) dioxane (8 mL)
2. temperatureUpon cooling to room temperature
3. additionthe reaction mixture was diluted with saturated aqueous NaHCO3
4. extractionextracted with ethyl acetate
5. washwashed with brine
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo
9. customThe residue was purified by silica gel column chromatography (ethyl acetate/toluene)

ORD record

ord-d1a448448c81421f80dda42c4b62d971

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09353066B2