Water → (1,3-dimethyl-1H-pyrazol-4-yl)methanamine
Reaction equation
Cl.Cl[C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[CH2:10][NH2:11].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>C1COCC1>[CH3:8][N:7]1[CH:3]=[C:4]([CH2:10][NH2:11])[C:5]([CH3:9])=[N:6]1Participants
5
Procedure
To a solution of compound 4 (120 mg, 0.61 mmol) in THF (5 mL) was added LAH (43 mg, 3.78 mmol). The resulting mixture was stirred at room temperature overnight. Water was added and the resulting mixture was filtered. Organic layer was separated and then concentrated in vacuum to give a white solid (crude product). LCMS (ESI) m/z=126 (M+H)+.
Workup
- filtrationthe resulting mixture was filtered
- customOrganic layer was separated
- concentrationconcentrated in vacuum
- customto give a white solid (crude product)
Sources & evidence
- ORD record
- ord-a602945824aa427dbe9dfe180f482602
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09353104B2
Reaction notes
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