Oxygen → 7-Aminocephalosporanic acid

HRID 53090Notes

Reaction equation

[CH3:1][C:2]([O:4][CH2:5][C:6]1[CH2:25][S:24][C@@H:9]2[C@H:10]([NH:13]C(CCC[C@@H](N)C(O)=O)=O)[C:11](=[O:12])[N:8]2[C:7]=1[C:26]([OH:28])=[O:27])=[O:3].O=O>>[CH3:1][C:2]([O:4][CH2:5][C:6]1[CH2:25][S:24][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:26]([OH:28])=[O:27])=[O:3]

Participants

Reactant 2

HCID 977Oxygen

HCID 65536Cephalosporin C

Product 1

HCID 4413287-Aminocephalosporanic acid

Procedure

combining in a reaction vessel cephalosporin C, catalase, D-amino acid oxidase obtained from T. variabilis strain ATCC 20931, externally supplied oxygen, and deacylase obtained from Acinetobacter sp. strain ATCC 53891 under conditions sufficient to produce 7-amino cephalosporanic acid; and

Workup

customcombining in a reaction vessel

Sources & evidence

ORD record: ord-2d5eb038d3a3466b9494e0115abc7250
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05618687

Reaction notes

Loading…