Methanol → 3-Methoxy-3-oxo-2-phenylpropanoic acid

HRID 53196

Reaction equation

HRID 53196 reaction equation
[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B(F)(F)F.[CH3:18]COCC.CO>>[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([O:10][CH3:18])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 8000Boron trifluoride etherateHCID 75791Phenylmalonic acid

Product 1

HCID 28177753-Methoxy-3-oxo-2-phenylpropanoic acid

Procedure

A mixture of phenylmalonic acid (3.6 g, 0.02 mol), boron trifluoride etherate (2.4 mL, 0.02 mol) and 0.8 mL of anhydrous methanol (0.02 mol) was refluxed and stirred for 24 hours. After cooling to room temperature, the reaction mixture was filtered and 20 mL of water was added.

Workup

  1. temperaturewas refluxed
  2. filtrationthe reaction mixture was filtered
  3. addition20 mL of water was added

Sources & evidence

ORD record
ord-f0626949f0464962af6e6c41c959ad1b
Source dataset
uspto-grants-1997_04
Patent number
US05618826

Linked notes

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