2-(2-Fluoropropoxy)-3-nitropyridine → 2-(2-Fluoropropoxy)pyridin-3-amine

HRID 532266

Reaction equation

HRID 532266 reaction equation
[F:1][CH:2]([CH3:14])[CH2:3][O:4][C:5]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][N:6]=1>C1COCC1.CO.[Pd]>[F:1][CH:2]([CH3:14])[CH2:3][O:4][C:5]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][N:6]=1

Participants

5

Reactant 1

HCID 584133052-(2-Fluoropropoxy)-3-nitropyridine

Product 1

HCID 584133852-(2-Fluoropropoxy)pyridin-3-amine

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

2-(2-fluoropropoxy)-3-nitropyridine (199.97 mg) was dissolved in a mixture of THF (10 ml) and methanol (5 ml). Pd/C (20 mg) was added and the mixture was hydrogenated at room temperature for 4 h and 3 bar. The mixture was concentrated in vacuo.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-cc68b35ccd2f43699ae394ab4323f65f
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Linked notes

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