Trifluoroacetic acid → HCID 67395207, compound
Reaction equation
[C:1]([C:4]1[S:32][C:7]2[N:8]=[CH:9][N:10]=[C:11]([NH:12][C:13]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:14]=3[O:15][CH:16]([CH3:26])[CH2:17][NH:18]C(=O)OC(C)(C)C)[C:6]=2[C:5]=1[CH3:33])(=[O:3])[NH2:2].[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>ClCCl>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[NH2:18][CH2:17][CH:16]([O:15][C:14]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:13]=1[NH:12][C:11]1[C:6]2[C:5]([CH3:33])=[C:4]([C:1]([NH2:2])=[O:3])[S:32][C:7]=2[N:8]=[CH:9][N:10]=1)[CH3:26]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
tert-Butyl 2-(2-(6-carbamoyl-5-methylthieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate (740 mg) was dissolved in dichloromethane (20 ml) and trifluoroacetic acid (4 ml) was added and the reaction was stirred at room temperature overnight. The reaction was concentrated in vacuo to give the title compound.