Hydrogen iodide → N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl)valeramide
Reaction equation
[CH3:1][N:2]([CH3:18])[C:3](=[O:17])[CH:4]([CH3:16])[CH:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14]C)[CH:9]=1)[CH2:6][CH3:7].I>>[CH3:18][N:2]([CH3:1])[C:3](=[O:17])[CH:4]([CH3:16])[CH:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[CH:9]=1)[CH2:6][CH3:7]Participants
3
Procedure
The steps are: add compound 7 into a reaction flask, add hydroiodic acid, perform heating and reflux for 5 hours; detect the reaction process by TLC; after that, cool the resultant to the room temperature, pour it to an alkaline solution to make the pH become 9, and perform extraction by ethyl acetate and rinse by water; and recycle the solvent after drying and decompression to obtain a light yellow liquid, N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl) valeramide (compound 9).
Workup
- temperatureperform heating
- temperaturereflux for 5 hours
- additionpour it to an alkaline solution