4-Nitrobenzaldehyde → 1-Boc-4-(4-Nitrobenzyl)piperazine
Reaction equation
[N+](C1C=CC(C=O)=CC=1)([O-])=O.N1(C(OC(C)(C)C)=O)CCNCC1.C[C@H:26]1[CH2:31][N:30]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([N+:39]([O-:41])=[O:40])=[CH:35][CH:34]=2)[CH2:29][CH2:28][N:27]1[C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43]>>[N+:39]([C:36]1[CH:35]=[CH:34][C:33]([CH2:32][N:30]2[CH2:31][CH2:26][N:27]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:28][CH2:29]2)=[CH:38][CH:37]=1)([O-:41])=[O:40]Participants
4
Procedure
The title compound was prepared from 4-nitrobenzaldehyde and 1,1-dimethylethyl 1-piperazinecarboxylate using a method similar to that described for D1 in Description 1A although the product was purified by column chromatography followed by passing through an SCX column eluting with MeOH then 2M NH3 in MeOH. MS (ES+): 266.1, 222.2, no molecular ion (MH+) observed.