Ethylamine → 2-Ethylamino-3-nitropyridine
Reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>C1(C)C(C)=CC=CC=1>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A stirred mixture of 2-chloro-3-nitropyridine (8.60 g, 0.054 mol), ethylamine (5.37 g, 0.12 mol), and xylene (10 ml) was heated at 100° C. in a sealed tube for three hours. After cooling, the solvent was removed in vacuo, and water was added to the residue. The product was extracted with methylene chloride, dried (sodium sulfate), and concentrated in vacuo to give 10.0 g of the title compound as a yellow oil, suitable for use in the next reaction.
Workup
- temperatureAfter cooling
- customthe solvent was removed in vacuo, and water
- additionwas added to the residue
- extractionThe product was extracted with methylene chloride
- dry with materialdried (sodium sulfate)
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-21666309bf514d1186b2c8f064342bce
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05620974
Reaction notes
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