N-Iodosuccinimide → HCID 178432607, compound
Reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][N:9]=[CH:10][C:5]2=[CH:4][N:3]=1.[I:11]N1C(=O)CCC1=O>CN(C=O)C>[I:11][C:10]1[C:5]2[C:6](=[N:7][C:2]([CH3:1])=[N:3][CH:4]=2)[NH:8][N:9]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
2.180 g (purity 73%, approx. 11.82 mmol) of 6-methyl-1H-pyrazolo[3,4-d]pyrimidine and 3.987 g (17.72 mmol) of N-iodosuccinimide were dissolved in 30 ml DMF and heated for 2 h at 80° C. After cooling, the mixture was concentrated in the rotary evaporator and the residue was mixed with dichloromethane, filtered with suction and dried under high vacuum. 7.950 g (approx. 38% purity) of the target compound was obtained.
Workup
- temperatureAfter cooling
- concentrationthe mixture was concentrated in the rotary evaporator
- additionthe residue was mixed with dichloromethane
- filtrationfiltered with suction
- customdried under high vacuum
- custom7.950 g (approx. 38% purity) of the target compound was obtained
Sources & evidence
- ORD record
- ord-1d4cadfa36524ffbb0d8d2eee00f7fd3
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08859569B2
Reaction notes
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