Hydrochloric Acid → 1H-Indazole-3-carboxylic acid, 1-methyl-
Reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([O:13]C)=[O:12])=[N:3]1.[OH-].[Na+].Cl>CO.O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=[O:12])=[N:3]1Participants
6
Procedure
A solution of 1-methylindazole-3-carboxylic acid, methyl ester (1.00 g, 0.0053 mol) was stirred in a mixture of methanol (10 mL)/2N NaOH solution (120 mL) at reflux temperature for 2 hours. After cooling, the mixture was diluted with water (100 mL) and acidified with 6N HCl solution. The white solid that formed was collected by filtration and dried under ambient conditions for 6 days to give 0.86 g (92% yield) of the product; mp 215°-216° C.
Workup
- temperatureat reflux temperature for 2 hours
- temperatureAfter cooling
- customThe white solid that formed
- filtrationwas collected by filtration
- customdried under ambient conditions for 6 days
Sources & evidence
- ORD record
- ord-76e193244c0648009545e2db9839eabd
- Source dataset
- uspto-grants-1993_09
- Patent number
- US05244907
Reaction notes
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