Methyl Acrylate → Methyl 3-[4-(3-Benzyloxyphenyl)-4-fluoro-3-methylpiperidin-1-yl]propionate
Reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:23])[CH2:21][CH2:20][NH:19][CH2:18][CH:17]2[CH3:22])[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:24]([O:28][CH3:29])(=[O:27])[CH:25]=[CH2:26]>>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:16]2([F:23])[CH2:21][CH2:20][N:19]([CH2:26][CH2:25][C:24]([O:28][CH3:29])=[O:27])[CH2:18][CH:17]2[CH3:22])[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1Participants
3
Procedure
This compound was prepared from 4-(3-benzyloxyphenyl)-4-fluoro-3-methylpiperidine hydrochloride and methyl acrylate as described in Step 1 of Example 4 in 81% yield.
Sources & evidence
- ORD record
- ord-474fc9bc1f19430799ee98378aeac3f7
- Source dataset
- uspto-grants-2014_10