Hydrochloric Acid → 4-Fluoro-2-(pyridin-4-yl)benzoic acid hydrochloride

HRID 538465

Reaction equation

[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH:3]=1.[ClH:18]>>[ClH:18].[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:12]2[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=2)[CH:3]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 46317422Methyl 4-fluoro-2-(pyridin-4-yl)benzoate

Product 1

HCID 866808554-Fluoro-2-(pyridin-4-yl)benzoic acid hydrochloride

Conditions

Temperature: 90 °C

Procedure

A mixture of methyl 4-fluoro-2-(pyridin-4-yl)benzoate (0.88 g) and 6 N hydrochloric acid (13 mL) was stirred at 90° C. for 18 hr. The solvent was evaporated under reduced pressure to give the title compound (0.96 g).

Workup

customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-ef6b15d2229d43bdb124746268372540
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08865717B2

Linked notes

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