Hydrochloric Acid → 4-Methyl-2-methylene valeric acid

HRID 538856

Reaction equation

HRID 538856 reaction equation
[CH2:1]([C:5](=[CH2:11])[C:6]([O:8]CC)=[O:7])[CH:2]([CH3:4])[CH3:3].Cl>[OH-].[K+]>[CH2:1]([C:5](=[CH2:11])[C:6]([OH:8])=[O:7])[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10909818Ethyl 4-methyl-2-methylenepentanoate

Product 1

HCID 1686594-Methyl-2-methylene valeric acidYield 99.1%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

Saponification of 6.32 g (40.4 mmol) ethyl 2-isobutylacrylate was carried out 50 ml of 20% aqueous KOH at reflux. The obtained mixture was acidified by aqueous HCl to pH=5-6, and the product was extracted by 2×100 ml of dichloromethane. The organic extract was evaporated to dryness to give 5.13 g (99%) 2-isobutylacrylic acid which was further used without an additional purification.

Workup

  1. temperatureat reflux
  2. extractionthe product was extracted by 2×100 ml of dichloromethane
  3. extractionThe organic extract
  4. customwas evaporated to dryness

Sources & evidence

ORD record
ord-61225128229a48d3a3819e2eb4be8673
Source dataset
uspto-grants-2014_10
Patent number
US08865848B2

Linked notes

Loading…