Reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9])N.NC1C=CC=CC=1O.[ClH:18]>S(C1C=CC(C)=CC=1)([O-])(=O)=O.CO>[ClH:18].[NH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
In the present invention, the starting material 2-hydrazinylphenol may be in tosylate form. The 2-hydrazinylphenol in tosylate form can be prepared by a process comprising the steps of: (a) dissolving 2-aminophenol in methanol and adding hydrochloride gas thereto to obtain 2-aminophenol hydrochloride (HCl); (b) dissolving the 2-aminophenol hydrochloride in ethanol and adding isopentyl nitrite thereto to make a nitramide intermediate; and (c) adding the intermediate to an ethanol solution containing para-toluenesulfonic acid (PTSA or TsOH) and tin chloride (SnCl2), thereby obtaining 2-hydrazinylphenol tosylate.
Sources & evidence
- ORD record
- ord-ee621668dccd43c4895e91a335bdd852
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08865934B2
Linked notes
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