Ferulic Acid → Dihydroferulic Acid

HRID 53970

Reaction equation

HRID 53970 reaction equation
[C:1]([OH:14])(=[O:13])/[CH:2]=[CH:3]/[C:4]1[CH:12]=[CH:11][C:9]([OH:10])=[C:6]([O:7][CH3:8])[CH:5]=1>CO.[C].[Pd]>[OH:10][C:9]1[CH:11]=[CH:12][C:4]([CH2:3][CH2:2][C:1]([OH:14])=[O:13])=[CH:5][C:6]=1[O:7][CH3:8]

Participants

4

Reactant 1

HCID 445858Ferulic Acid

Product 1

HCID 14340Dihydroferulic AcidYield 95.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

20.0 g of Ferulic acid was dissolved in 250 ml of methanol and subjected to catalytic reduction under normal pressure for 3 hours in the presence of 10% palladium carbon catalyst (50% wet type). After removing the catalyst by filtration, the resulting filtrate was concentrated to collect precipitated crystals by filtration, thereby obtaining 19.3 g of 3-(4-hydroxy-3-methoxyphenyl)propionic acid.

Workup

  1. customAfter removing the catalyst
  2. filtrationby filtration
  3. concentrationthe resulting filtrate was concentrated
  4. customto collect
  5. customprecipitated crystals
  6. filtrationby filtration

Sources & evidence

ORD record
ord-82b17ac5b1d24f1eb4c9fd8d2d950180
Source dataset
uspto-grants-1997_04
Patent number
US05620991

Linked notes

Loading…