1-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one → 1,6-Naphthyridine-2,4(1H,3H)-dione

HRID 539943

Reaction equation

HRID 539943 reaction equation
C([N:8]1[C:17]2[C:12](=[CH:13][N:14]=[CH:15][CH:16]=2)[C:11]([OH:18])=[CH:10][C:9]1=[O:19])C1C=CC=CC=1>FC(F)(F)S(O)(=O)=O>[NH:8]1[C:17]2[C:12](=[CH:13][N:14]=[CH:15][CH:16]=2)[C:11](=[O:18])[CH2:10][C:9]1=[O:19]

Participants

3

Reactant 1

HCID 712553201-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one

Product 1

HCID 691080981,6-Naphthyridine-2,4(1H,3H)-dione

Reagents, catalysts & solvents 1

HCID 62406Trifluoromethanesulfonic acidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 1-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one (21 g, 0.08 mol) and trifluoromethanesulfonic acid (100 mL) was heated with stirring at 120° C. overnight. The reaction mixture was used for the next step directly.

Workup

  1. temperaturewas heated

Sources & evidence

ORD record
ord-6eec20b939d6490a8d658d34fc4f323a
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Linked notes

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