Trifluoroacetic acid → HCID 178525610, compound
Reaction equation
FC(F)(F)C(O)=O.[OH:8][CH:9]([C:18]1[N:19]=[CH:20][N:21](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:22]=1)[CH2:10][C:11]([O:13]C(C)(C)C)=[O:12]>ClCCl>[OH:8][CH:9]([C:18]1[N:19]=[CH:20][NH:21][CH:22]=1)[CH2:10][C:11]([OH:13])=[O:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3 ml of trifluoroacetic acid are added to a solution of 1.4 g (3 mmol) of tert-butyl 3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)propanoate in 7 ml of dichloromethane. After stirring for 4 hours at ambient temperature, the reaction medium is concentrated. 0.5 g of crude product is used directly in the next stage.
Workup
- concentrationthe reaction medium is concentrated
Sources & evidence
- ORD record
- ord-502f1f63e082417dae53fc084bc1e4e3
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08871187B2
Reaction notes
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