Hydrazine hydrate (1:1) → Oxolane-3-carbohydrazide

Into around-bottom flask, was placed hydrazine hydrate (20 mL). To this was added methyl tetrahydrofuran-3-carboxylate (compound 38.1, 390 mg, 3.00 mmol, 1.00 equiv) dropwise with stirring. The resulting mixture was stirred at 50° C. in an oil bath. After 3 h, the reaction mixture was concentrated and dried under reduced pressure to yield 0.29 g (74%) of the title compound as a colorless oil.

1. customInto around-bottom flask, was placed
2. stirringThe resulting mixture was stirred at 50° C. in an oil bath
3. concentrationthe reaction mixture was concentrated
4. customdried under reduced pressure

ORD record

ord-38f8c1db6fa54ce0ab4ba1364e836a24

Source dataset

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08871790B2