Hydrochloric Acid → methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

Reaction equation

[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([OH:7])=[O:6].[CH3:13]O>>[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([O:7][CH3:13])=[O:6]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 12879199(2RS,3S)-3-amino-2-hydroxy-5-methylhexanoic acid

Product 1

HCID 13746619methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

Procedure

Hydrogen chloride was passed into a solution 110 mg of (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoic acid in 10 ml of methanol under ice-cooling, and the mixture was stirred overnight. The reaction mixture was evaporated to dryness under reduced pressure to obtain 150 mg of methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride as a white powder.