Hydrogen Bromide → 5-(4-Aminophenyl)-3-methyl-2(1H)-pyrazinone hydrobromide
Reaction equation
C(OC([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:19]=[C:20]([CH3:25])[C:21](=[O:24])[NH:22][CH:23]=2)=[CH:14][CH:13]=1)=O)C1C=CC=CC=1.[BrH:26]>C(O)(=O)C>[BrH:26].[NH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[N:19]=[C:20]([CH3:25])[C:21](=[O:24])[NH:22][CH:23]=2)=[CH:16][CH:17]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5-(4-Benzyloxycarbonylaminophenyl)-3-methyl-2(1H)pyrazinone (1.5 g) was treated with hydrogen bromide in acetic acid in a manner similar to that described in Example 20 to give the title compound as its hydrobromide salt (1.09 g) which on recrystallisation from ethanol/ether has m.p. >300° C.; ν(Nujol mull) 1632, 1640 cm-1.
Sources & evidence
- ORD record
- ord-243e3a70be064ea88fee6a8ffaa8246e
- Source dataset
- uspto-grants-1987_04
- Patent number
- US04657906
Reaction notes
Loading…