Hydrochloric Acid → Trans-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid
Reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([NH:13][C:14]([C@H:16]2[CH2:19][CH2:18][C@H:17]2[C:20]([OH:22])=[O:21])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Cl>[OH-].[Na+]>[F:1][C:2]([F:23])([F:24])[C:3]1[CH:4]=[C:5]([NH:13][C:14]([C@@H:16]2[CH2:19][CH2:18][C@H:17]2[C:20]([OH:22])=[O:21])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:10])[F:11])[CH:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5.0 g of cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid was reacted at a temperature of 50° C. for three hours in 10% aqueous caustic soda solution. The products were neutralized with dilute hydrochloric acid, extracted with ethyl acetate and then recrystallized from acetonitrile to give 3.4 g of the title compounds (yield: 68%).