Hexamethylenetetramine → HCID 20206377, compound

Reaction equation

Cl.N[CH2:3][C:4]1[CH:9]=[C:8]([CH:10]([CH3:13])[CH2:11][CH3:12])[CH:7]=[C:6]([S:14]([CH3:17])(=[O:16])=[O:15])[C:5]=1[OH:18].C1N2CN3CN(C2)CN1C3.FC(F)(F)C(O)=[O:32]>>[CH:3]([C:4]1[CH:9]=[C:8]([CH:10]([CH3:13])[CH2:11][CH3:12])[CH:7]=[C:6]([S:14]([CH3:17])(=[O:16])=[O:15])[C:5]=1[OH:18])=[O:32]

Participants

Reactant 3

HCID 4101Hexamethylenetetramine

HCID 6422Trifluoroacetic acid

HCID 20206369HCID 20206369, compound

Product 1

HCID 20206377HCID 20206377, compound

Procedure

0.48 g (0.0016 mol) of 2-aminomethyl-4-(1-methylpropyl)-6-methylsulfonylphenol hydrochloride is reacted with 0.22 g of hexamethylenetetramine in 3 ml of trifluoroacetic acid in analogy to Example 1. Melting point: 68°-70° C.

Sources & evidence

ORD record: ord-5b2dd1cae8a04719ad8ed844081ee5de
Source dataset: uspto-grants-1987_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04661636

Reaction notes

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