Water → 4-Trifluoromethyl-1,2-phenylenediamine

HRID 54407

Reaction equation

HRID 54407 reaction equation
[N+:1]([C:4]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-])=O.Cl[Sn]Cl.O.C([O-])(O)=O.[Na+]>C(O)C>[F:12][C:11]([F:13])([F:14])[C:9]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([NH2:1])[CH:10]=1

Participants

6

Reactant 4

HCID 962WaterHCID 24479Stannous ChlorideHCID 67865Benzenamine, 2-nitro-4-(trifluoromethyl)-HCID 516892Sodium Bicarbonate

Product 1

HCID 5208224-Trifluoromethyl-1,2-phenylenediamineYield 96.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-nitro-4-trifluoromethylaniline (5.000 g, 24.26 mmol, Aldrich, used as received) and SnCl2.2 H2O (20.00 g, 88.64 mmol, Aldrich, used as received) in absolute ethanol (50 mL) was refluxed for 45 min. It was then poured into ice (85 g) and basified with 10% aq. NaHCO3 (250 mL). The resulting suspension was extracted with ethyl acetate (400 mL). The ethyl acetate extract was dried over Na2SO4 and evaporated to give 4.14 g (87%) of pure 4-trifluoromethyl-1,2-phenylenediamine as a red powder.

Workup

  1. extractionThe resulting suspension was extracted with ethyl acetate (400 mL)
  2. extractionThe ethyl acetate extract
  3. dry with materialwas dried over Na2SO4
  4. customevaporated

Sources & evidence

ORD record
ord-62109381f5f14189913bf106ba37e015
Source dataset
uspto-grants-1997_04
Patent number
US05622952

Linked notes

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