Ammonium Chloride → 3-Methoxy-5-isoxazolemethanol
Reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([C:8](OCC)=[O:9])[O:5][N:4]=1.[BH4-].[Li+].[Cl-].[NH4+]>O1CCCC1>[OH:9][CH2:8][C:6]1[O:5][N:4]=[C:3]([O:2][CH3:1])[CH:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 7.0 g 3-methoxy-5-carbethoxy-isoxazole in 80 ml tetrahydrofuran a 2m solution of lithiumborohydride in tetrahydrofuran was added at 15°-20° C. The reaction mixture was stirred for 2 h at room temperature, then poured into saturated ammoniumchloride solution and extracted with dichloromethane. The organic phase was dried over magnesium sulfate and evaporated togive 4.87 g alcohol.
Workup
- extractionextracted with dichloromethane
- dry with materialThe organic phase was dried over magnesium sulfate
- customevaporated togive 4.87 g alcohol
Sources & evidence
- ORD record
- ord-7ec27cc78268492a9df98576216b4907
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05622953
Reaction notes
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