Lithium azide → 1-Azido-1-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

HRID 54515

Reaction equation

HRID 54515 reaction equation
Cl[CH:2]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:10]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.[N-:16]=[N+:17]=[N-:18].[Li+]>CN(C)C=O>[N:16]([CH:2]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:10]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1)=[N+:17]=[N-:18]

Participants

4

Reactant 2

HCID 88163Lithium azideHCID 199594231-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

Product 1

HCID 199594151-Azido-1-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.92 g of 1-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane are added under argon to a solution of 0.37 g of lithium azide in 2 ml of dry dimethylformamide and the reaction mixture is stirred at 60° for 18 hours. Working up according to process A (see Example 1) gives the substance as a yellowish oil.

Workup

  1. customgives the substance as a yellowish oil

Sources & evidence

ORD record
ord-a1872d4c2faa42f194f06d6f8cbe80f7
Source dataset
uspto-grants-1997_04
Patent number
US05622982

Linked notes

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